Sabine Specht Selected Research

Filariasis

12/2021	Evaluation of the in vitro susceptibility of various filarial nematodes to emodepside.
12/2021	Onchocerciasis drug development: from preclinical models to humans.
1/2020	Oxfendazole mediates macrofilaricidal efficacy against the filarial nematode Litomosoides sigmodontis in vivo and inhibits Onchocerca spec. motility in vitro.
12/2014	Repurposing of approved drugs from the human pharmacopoeia to target Wolbachia endosymbionts of onchocerciasis and lymphatic filariasis.
9/2012	Over expression of IL-10 by macrophages overcomes resistance to murine filariasis.
7/2012	Corallopyronin A specifically targets and depletes essential obligate Wolbachia endobacteria from filarial nematodes in vivo.
1/2012	Immunization with L. sigmodontis microfilariae reduces peripheral microfilaraemia after challenge infection by inhibition of filarial embryogenesis.
11/2004	Interleukin-10 (IL-10) counterregulates IL-4-dependent effector mechanisms in Murine Filariasis.
12/2003	Synergism of gamma interferon and interleukin-5 in the control of murine filariasis.
2/2003	Murine filariasis: interleukin 4 and interleukin 5 lead to containment of different worm developmental stages.

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Sabine Specht Research Topics

Disease

25	Onchocerciasis 01/2022 - 09/2008
23	Infections 01/2019 - 02/2003
10	Filariasis 12/2021 - 02/2003
8	Filarial Elephantiasis (Lymphatic Filariasis) 12/2021 - 09/2006
7	Intestinal Volvulus (Volvulus) 12/2015 - 11/2009
5	Ocular Onchocerciasis (River Blindness) 10/2021 - 03/2013
5	Neglected Diseases 01/2021 - 03/2013
5	Inflammation (Inflammations) 01/2018 - 02/2008
5	Cerebral Malaria 01/2018 - 08/2010
4	Loiasis 12/2021 - 01/2009
4	Malaria 01/2019 - 01/2008
2	Coinfection 01/2019 - 09/2008
2	Infertility (Sterility) 01/2018 - 08/2015
2	Lymphedema (Milroy Disease) 09/2012 - 09/2006
2	Proteinuria 03/2008 - 02/2005
1	Muscular Atrophy (Muscle Atrophy) 11/2022
1	Muscular Diseases (Myopathy) 11/2022
1	Body Weight (Weight, Body) 01/2022
1	Motor Neuron Disease (Primary Lateral Sclerosis) 07/2021
1	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 07/2021
1	Muscle Spasticity (Spastic) 06/2021
1	Paralysis (Palsy) 06/2021
1	Trachoma 01/2021
1	Helminthiasis (Helminthiases) 01/2021
1	Larva Migrans (Cutaneous Larva Migrans) 01/2021
1	Muscle Hypotonia (Hypotonia) 01/2021
1	Schistosomiasis (Bilharziasis) 01/2021
1	Muscular Dystrophies (Muscular Dystrophy) 01/2021
1	Myiasis (Myiases) 01/2021
1	Strongyloidiasis 01/2021
1	Limb-Girdle Muscular Dystrophies (Limb-Girdle Muscular Dystrophy) 01/2021
1	Scabies (Sarcoptic Mange) 01/2021
1	Parasitic Diseases (Parasitic Disease) 01/2021
1	Trichuriasis 01/2021
1	Asymptomatic Diseases 01/2020
1	Necrosis 01/2018
1	Ileus 01/2018
1	Reinfection 04/2015
1	Sepsis (Septicemia) 01/2015
1	Hydrops Fetalis (Fetal Edema) 02/2014

Drug/Important Bio-Agent (IBA)

16	Doxycycline (Periostat)FDA LinkGeneric 01/2019 - 09/2006
15	Pharmaceutical PreparationsIBA 01/2022 - 09/2006
11	Interleukin-10 (Interleukin 10)IBA 01/2018 - 11/2004
8	Ivermectin (Mectizan)FDA Link 01/2021 - 09/2008
8	CytokinesIBA 01/2019 - 12/2003
7	Interleukin-5 (Interleukin 5)IBA 03/2015 - 02/2003
6	Anti-Bacterial Agents (Antibiotics)IBA 01/2019 - 11/2008
6	Proteins (Proteins, Gene)FDA Link 05/2017 - 02/2005
4	AntigensIBA 12/2015 - 03/2008
3	emodepsideIBA 01/2022 - 10/2021
3	Interleukin-13IBA 03/2015 - 11/2004
3	Interleukin-4 (Interleukin 4)IBA 03/2006 - 02/2003
2	Minocycline (Cyclops)FDA LinkGeneric 01/2019 - 01/2017
2	ChemokinesIBA 01/2018 - 01/2015
2	Biomarkers (Surrogate Marker)IBA 12/2015 - 03/2013
2	Immunoglobulin G (IgG)IBA 12/2015 - 01/2012
2	Peptide Hydrolases (Proteases)FDA Link 08/2013 - 11/2009
2	Rifampin (Rifampicin)FDA LinkGeneric 07/2012 - 11/2008
2	Interferon-gamma (Interferon, gamma)IBA 09/2011 - 12/2003
2	Interleukin-12 (IL 12)IBA 09/2011 - 03/2006
2	Vascular Endothelial Growth Factor CIBA 12/2009 - 09/2006
1	Creatine Kinase (Creatine Phosphokinase)IBA 11/2022
1	SphingolipidsIBA 07/2021
1	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA 06/2021
1	oxantel pamoateIBA 06/2021
1	Laminin (Merosin)IBA 01/2021
1	oxfendazoleIBA 01/2020
1	AmidesIBA 01/2020
1	ElementsIBA 01/2020
1	benzimidazoleIBA 01/2020
1	SolutionsIBA 01/2019
1	flubendazoleIBA 01/2019
1	Tetracycline (Achromycin)FDA LinkGeneric 01/2019
1	Protozoan RNAIBA 01/2019
1	MacrolidesIBA 01/2019
1	Immunoglobulin E (IgE)IBA 01/2018
1	InterleukinsIBA 01/2018
1	RNA (Ribonucleic Acid)IBA 01/2018
1	Albendazole (Albenza)FDA Link 01/2017
1	N 30IBA 01/2017
1	NucleotidesIBA 12/2016
1	muramyl- NAc- (pentapeptide)pyrophosphoryl- undecaprenolIBA 12/2016
1	Acetylmuramyl-Alanyl-IsoglutamineIBA 12/2016
1	Mannose ReceptorIBA 01/2016
1	Cannabinoid Receptors (Cannabinoid Receptor)IBA 01/2016
1	GlucuronidesIBA 12/2015
1	N-acetyltyramineIBA 12/2015
1	AntibodiesIBA 12/2015
1	ProteomeIBA 12/2015
1	Interleukin-17 (Interleukin 17)IBA 03/2015
1	Merozoite Surface Protein 1 (MSA1)IBA 03/2015
1	Interleukin-6 (Interleukin 6)IBA 03/2015
1	Propranolol (Inderal)FDA LinkGeneric 02/2014

Therapy/Procedure

6	Mass Drug Administration 12/2021 - 01/2012
6	Therapeutics 04/2015 - 09/2008
2	Drug Therapy (Chemotherapy) 01/2021 - 01/2008
2	Aftercare (After-Treatment) 04/2015 - 09/2006
2	Immunomodulation 01/2015 - 08/2010
1	Continuous Positive Airway Pressure 11/2022
1	Induced Hypothermia 01/2015